Alison Bass, Your Facts on Helen Mayberg Are Wrong, Wrong, and Wrong

31 Aug 2013: The public memo below, asking jouranlist Alison Bass to correct serious errors she published in a November 2010 post at her site, was originally published at my Posterous site in late 2010, soon after her post. I wrote it because a) Bass had failed to correct her original post with the false accusations, despite a comment I lodged there making it clear she had erred and b) she wrote another post about Mayberg in which she referred back to her erroneous post.  in  I wrote it in 2011 as a comment responding to Bass’s post, but despite several attempts I could not get it through her comment system. Later, in another, May 2011 post full of sloppy allegations, Bass accused me of “cleaning up” Mayberg’s Wikipedia page — an extremely serious charge. She later retracted that accusation —  but also erased the comment in which I had pointed it out, which rather fogs the record. A PDF of a screenshot of that erased corrective comment, made before Bass erased it, is here. It makes more clear how serious a mistake she made, and how sloppy she was willing to be to accuse both Mayberg and me of unethical behavior.
I have reposted this 31 Aug 2013, but dated November 11, 2011 (its original pub date), when I realized that because Posterous ceased operation in 2013, this correction was no longer publicly available, and, alas, people are still citing Bass’s post as reasons not to trust Mayberg’s work (or me). (See, for instance, my comment here correcting John Horgan’s repetition of Bass’s charges.)  As of today, Bass has never responded to my requests for correction.
Extra note: In a few places here, I’ve changed copy to replace phrases that cited links that no longer exist. I’ve also made a few small changes to correct typos or grammatical mistakes. The more substantial such changes appear as strikethroughs for deletions, underlines for replacement copy.

An appeal to Alison Bass:

Alison, when I attempted to correct your errors before, I was less than brutally frank, was in fact rather generous, methinks, because I wanted to leave you a graceful way to admit error. But I see you have doubled down. I’d as soon put this behind us. But it’s important to correct the record, which you have filled with false and easily falsifiable information.

So let me say more directly: In virtually everything you accuse Mayberg of in both your May 2011 post and your earlier, November 2010 post, you are wrong. You are wrong in your facts. You are wrong in your assessment of Helen Mayberg’s priorities,  motives, and character. And you are wrong, and seem to insist on continuing to be wrong even when presented with evidence that would have allowed you to correct your error.

Let’s take your points one at a time.

Mayberg’s alleged failure to disclose data.

You repeatedly assert, in both your posts, that in her talk about her work at the National Association of Science Writers meeting in November, 2010, Mayberg did not report the data on the 20 patients in her Toronto study. This is false. Mayberg DID report the data on the Toronto study. She did not give the data on a separate Atlanta study, because that Emory/Atlanta study is still unpublished. But she did report the data on the Toronto patients, and I told you that the day after you published your first post soon after the conference — but you left the original accusation standing and keep repeating that she did not report it.

Again, I feel a bit stupid repeating this correction, but do so because saying it only once before apparently didn’t work: Mayberg showed the data you say she didn’t show. She showed a slide with the data, and she talked in specifics about the patients’ outcomes as well. She noted improvement in 60% of the patients and full remission in 35%.

Is that data encouraging or otherwise significant?

You think not, and in fact you imply that Mayberg is making a big deal out of unimpressive data that is “not encouraging.” You say you’re not impressed with 35% full remission in patients who were almost inconceivably depressed. That’s your prerogative.

But readers should understand what response and remission means in this group of 20 patients she treated in her pilot study. Mayberg related all of this at her talk. As she said then, full remission, by the most common depression standard, means reducing symptoms enough that a patient won’t score as depressed in the Hamilton Depression Scale.

The very top score possible in the Hamilton scale is 38. To be not depressed or in remission, you need to score under 8.

Here’s the scale:

0-7 = Normal

8-13 = Mild Depression

14-18 = Moderate Depression

19-22 = Severe Depression

≥ 23 = Very Severe Depression

Most of us have never seen people with scores over 20, for those people rarely get out and about. Their lives are deeply, intensely miserable. They were catastrophically, almost catatonically depressed.

The average score of the patients in Mayberg’s Toronto trial was 25. (If I remember correctly, all scored over 20.) All had been severely depressed for years despite multiple drug treatments, CBT, and, for 17 of them, electroconvulsive therapy (ECT). None  — none — had ever responded significantly or lastingly to any other treatment, including (for 17 of the 20) ECT.

This was by design. Mayberg didn’t want to do an experimental treatment on people who had not exhausted every possible remedy. But this meant her patients for this pilot study were people for whom nothing worked, and who remained horrifically depressed, in an especially excruciating sort of hell. To be scored as cured — to reach remission — these deeply sick patients had to be brought to a Hamilton score below 8. Their depression scores had to be cut, in other words, by some 65%.

To Mayberg’s experimental treatment, as you note, 60% had significant response, and 35% fully remitted. The average Hamilton score dropped from 25 to 15 — even though about a third didn’t quality as responders, because their scores didn’t drop more than 15%. (Mayberg is trying to figure out why those didn’t respond; she wants to either figure out how to make them well or identify why this procedure can’t make them well, if that’s the case, so she won’t needlessly use an intrusive treatment on people who won’t respond.)

Meanwhile, 35% of these patients achieved full remission. That is, they went from the most excruciating, debilitating depression to normal. Most of the other 25% who did respond went into the moderate or mild range — the low teens, and some the upper single digits, of the Hamilton scale. They were still depressed. But they again had lives.

You assert that this is not impressive. The patients thought it was. It is also scientifically significant: Even as you throw stones at delusory targets, Mayberg’s work is helping to displace the neurochemical model of depression that has led to the egregious overuse of largely ineffective antidepressant drugs that you and I have both rightly lamented.

We can argue, of course, over whether 60% response and 35% remission in the 20 Emory patients is “encouraging.” But we should not be arguing over whether Mayberg disclosed that information at the talk. She reported it quite explicitly, and it’s in the published literature, as I told you before in comments attempting to correct your errors at the previous post, even providing the  links (paper; pdf). She published the Toronto data and talked explicitly of it at NASW, where she also showed a slide of it. Yet you keep saying she’s hiding it and ask why she didn’t tell us about it at the talk.

Did Mayberg disclose her industry ties?

You say she didn’t. She did. She noted she received equipment donations and that she had consulted for ANS/St. Jude Medical. She showed this information in a slide during the talk, and at my request today sent the slide to me today. Here is exactly what it says:


Off-label usage: DBS electrodes/pulse generators manufacturers: Medtronics, St. Jude Medical

Patent: US2005/0033379A1 (co-inventor Andres Lozano) issued March 2008, SJM assignee. Licensed to ANS/St. Jude Medical 2003

Consultant: St. Jude Medical (Neuromodulation Division)

This was the second slide of the talk (after the title slide). She drew attention to it by saying she wanted to make some disclosures. The information shown above was the slide’s only content. The letters were cleanly laid out and plenty big enough to read, and she left it up there long enough for anyone interested — as you claim to have been — to read it.

It’s not terribly ambiguous. Many of these relevant interests were also listed on later slides that described the results of individual studies. I myself do not recall exactly what she said out loud about any consultancy with ANS, and there’s no video posted, so I can’t check. But I do remember her drawing attention to her relationships, and, more to the point, the consultancy was plainly and explicitly listed on the slide.

Given your intense interest in her disclosures, I don’t understand how you missed these disclosures. But you did. Your repeated accusation that she failed to disclose her consultancy is just plain wrong. You complain that you thought St. Jude Medical was a hospital, and you imply that your confusion arose from some intention of Mayberg’s to deceive. Yet Mayberg disclosed both ANS and St Jude Medical as partners in the research (see slide contents above), and she identified ANS as a device maker and as a consultancy client. St Jude Medical is the company that bought ANS. So in separately identifying ANS and St Jude Medical, Mayberg effectively twice named the entity in question, which is, and has been since 2005, ANS/St. Jude Medical, the instrument maker. That you mistook one of those names as that of a hospital named St. Jude Medical Center— a hospital that apparently has a neuromodulation division, at least in your read of the slide— does not mean Mayberg was trying to mislead you. It means you made a mistake. If Mayberg had been wanting to mislead you, she would not have listed ANS; she would not have opened her talk with a slide and comments about disclosures; and she would not have listed those relationships on it.

You’re making a tangle of a simple truth here. Mayberg made no attempt to hide these relationships; she in fact offered an explicit right-up-front disclosure of them in her second slide; and she simply did not make the failures to disclose you accuse her of. Your memory and impression, as well as your account and accusations, directly contradict the reality that was before you and several hundred others that day.

“History of failure to disclose…”  

Here you are almost half-right but actually, alas, again completely wrong. When the Nemeroff et al VNS paper you refer to above was published in 2006, the paper did indeed fail to disclose conflicts of interest.

However, your accusation that Mayberg failed to disclose is wrong. She did disclose. She and the other authors all disclosed their interests (they were paid for their time in a working group that did the review that was published), as was requested by a journal editor. But for some reason — and whatever it was, it was not under Mayberg’s control — the journal did not publish that disclosure paragraph in the print issue or the original web version. Later the journal published a corrected version with proper disclosures online.

This is obviously not ideal. But again, the failure was the journal’s, not Mayberg’s. She disclosed; the journal didn’t. The journal’s failure became a big deal because the lead author, Howard Charles Nemeroff, who was head of Emory psychiatry at the time (and thus Mayberg’s new boss; she had recently moved to Emory from Toronto), was the journal’s top editor and had been involved in other failures to disclose. Nemeroff indeed did have a history of failure to disclose. And the failure on this paper was not, as your post above seems to suggest, the sole reason he lost the chairmanship. It was just the final straw.

Mayberg, however, disclosed her interest — but the journal didn’t print them. Thus you err in saying she failed to disclose. I can understand you concluding that she didn’t disclose, since no disclosure was originally printed. But the fact remains that you are wrong in saying she did not. This is not a trivial distinction, since you use this one failure to disclose to claim she had “a history of failure to disclose.”

Altogether, of course, the VNS paper was problematic, for several reasons: among them, because of the failure to disclose; because the company’s input created conflicts; and because the first draft was reportedly written, either largely or in part, by a ghostwriter, who was thanked in the acknowledgments but not listed as an author. (A Cyberonics scientist also took part but was listed as an author.) Such ghostwriting is a practice that many, including me, find questionable.

So what are we to make of Mayberg’s participation in this review and her co-authorship of this paper? It’s obviously not her finest moment. But to know what to make of it, we must ask whether that episode appears to be part of a pattern of behavior and an acceptance of serious conflicts of interest and failures to disclose, or whether it seems to be an aberration that she learned from. I would argue the latter. Mayberg’s conduct before and since then suggests that was the case. She does not court or accept big lucrative relationships or sponsorships with device makers — even though some of those makers would very, very much like to have such relationships with her. She assiduously avoids the sort of hype and commercialization that is far too common in the medical device industry. She takes pains to describe her procedure as experimental, a pilot, and in need of double-blinded trials. She always notes that it’s appropriate for only a tiny portion of the depressed population. And I don’t believe you’ll find her name on any more ghostwritten papers. She saw the ugly, and she recoiled.

Aside from that stands another, more proximate problem in your post of May 2011: You have used that one failure to disclose, which was the journal’s failure, rather than Mayberg’s, along with other failures-to-disclouse of which you falsely her (at the NASW talk), to assert in your very headline that Mayberg has a “history of failures to disclose conflicts of interest.” As I just explained, your VNS example is flawed, false, and erroneous — she didn’t fail, the journal did. And your NASW example is demonstrably, completely wrong. So where is the rest of this history?

Getting it wrong

Getting the facts wrong is not good, but, well, it happens. The bigger problem in all this is that you  so eagerly harness these errors — and so far refuse to acknowledge or correct them — in an effort to paint Mayberg as someone she is not: as someone who oversells results, hides data, and exploits her research, and by implication her patients, for financial gain. There are people out there like that, and I fully support and indeed take part in criticizing them. They are the bane of medicine.

But here you have mistaken your mark. Helen Mayberg is not the shill you suggest. Rather, she is and has always been a) deeply concerned with figuring out a model of depression to replace the flawed neurochemical model that has led to so much overmedication; b) intensely, deeply, movingly concerned with the welfare of her patients; and c) consistently vocal in her concern that this treatment not be overused or oversold. One of her patients wrote you to tell you this, and of Mayberg’s caution about expectations in generating expectations about the treatment. The patient describes Mayberg’s caution as almost excessive. I saw that myself. When I did the reporting for the story I wrote about her work in the Times in 2006, Mayberg took pains to convey — and urged me to include in the story —  her concern that the treatment might become too trendy and get used too widely and by people who didn’t use it well and/or on patients who were not as depressed and without other options as the patients she works on.

So to sum — and if I repeat myself, it’s because saying all this once already seemed to have no effect — your posts assert two main things: that Mayberg failed to disclose relationships and data in the talk at NASW, which she in fact did plainly disclose and discuss; and that she has a history of failure to disclose, which failure does not exist. You also assert, by implication and in your direct use of accusations based on facts that don’t exist, a cynical and erroneous assessment of her motives, principles, and character.

Quite frankly, you seem to carry a bias so dense that facts cannot penetrate it. You fail to see and hear things plainly displayed and said before you. You fail to acknowledge corrections when they are offered in good faith. It’s as if you went to her NASW talk having perceived some cues — device maker; depression treatment; past association with Nemeroff — that provoked a conditioned response — Attack — and a confirmation bias that nothing can penetrate.

Your target image went faulty. Mayberg simply isn’t what you think she is, and she has not done the things of which you accuse her. I’m at the neuroscience meeting as I write this, and a couple of days ago I was talking, not for attribution, to a medical ethicist: someone keenly aware of the dangers of conflicts of interest. This person knows Mayberg not by chance, but because Mayberg too is keenly concerned with conflicts of interest, and because she has talked with this person both in private conversations and in public and semi-public conversations at conferences about the use of medical devices, about conflicts of interest and the eagerness of some in the medical device community, both doctors and companies, to oversell the effectiveness of devices so as to make money. I told this person about Mayberg’s talk and your accusations. This person laughed and said, “She’s  whacking Mayberg? Picked the wrong example. It’s hard to think of someone who’s more careful about these things.”

If we journalists are to have credibility when we call out conflicts of interest, we need to check our facts, and if we get them wrong, we need to acknowledge that when corrected. I’d be pleased to see you do that in this case.


  1. It is amazing that Ms. Bass has not acknowledged her errors in reporting. Errors are human, it is the fact that she seems O.K. with not correcting the misinformation when her mistake reflects negatively on someone in the industry that genuinely has demonstrated such ethical behavior over the years. For those who have suffered from this severe form of depression, her continued dedication to her research is critical. There are plenty of people who legitimately deserve to be exposed. I would expect that a person at your level within the writing profession would act more responsibly by fact checking before making such negative character attacks and have the integrity to to correct mistakes when your information is verified as incorrect. As a patient of Dr. Mayberg’s for years, I have yet to experience anything but an incredibly dedicated physician, and I am a cynic by nature. I can’t believe you will continue within your profession with any credibility if you continue to exhibit this irresponsible behavior regarding your subjects.

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